Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Cervix Carcinoma
SUBMITTER: ROMINA CEJAS
LAB HEAD: FERNANDO J IRAZOQUI
PROVIDER: PXD013484 | Pride | 2019-04-17
REPOSITORIES: Pride
Cejas Romina B RB Lorenz Virginia V Garay Yohana C YC Irazoqui Fernando J FJ
The Journal of biological chemistry 20181227 9
Biological functions of nuclear proteins are regulated by post-translational modifications (PTMs) that modulate gene expression and cellular physiology. However, the role of <i>O-</i>linked glycosylation (<i>O</i>-GalNAc) as a PTM of nuclear proteins in the human cell has not been previously reported. Here, we examined in detail the initiation of <i>O-</i>GalNAc glycan biosynthesis, representing a novel PTM of nuclear proteins in the nucleus of human cells, with an emphasis on HeLa cells. Using ...[more]