Hypoxic regulation of the inflammatory lung neutrophil proteome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Lung, Neutrophil
SUBMITTER: 
Emily Watts
LAB HEAD: Sarah Ruth Walmsley
PROVIDER: PXD013672 | Pride | 2021-04-08
REPOSITORIES: Pride
Publications
Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism.
Watts Emily R ER Howden Andrew Jm AJ Morrison Tyler T Sadiku Pranvera P Hukelmann Jens J von Kriegsheim Alex A Ghesquiere Bart B Murphy Fiona F Mirchandani Ananda S AS Humphries Duncan C DC Grecian Robert R Ryan Eilise M EM Coelho Patricia P Blanco Gio Rodriguez GR Plant Tracie M TM Dickinson Rebecca S RS Finch Andy A Vermaelen Wesley W Cantrell Doreen A DA Whyte Moira K MK Walmsley Sarah R SR
The Journal of clinical investigation 20210501 10
Limiting dysfunctional neutrophilic inflammation while preserving effective immunity requires a better understanding of the processes that dictate neutrophil function in the tissues. Quantitative mass-spectrometry identified how inflammatory murine neutrophils regulated expression of cell surface receptors, signal transduction networks, and metabolic machinery to shape neutrophil phenotypes in response to hypoxia. Through the tracing of labeled amino acids into metabolic enzymes, proinflammatory ...[more]
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