Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Haemophilus Haemolyticus
TISSUE(S): Cell Culture
SUBMITTER: Richard Wilson
LAB HEAD: Dr Richard Wilson
PROVIDER: PXD013687 | Pride | 2019-05-29
REPOSITORIES: Pride
Molecular microbiology 20191202 2
Commensal bacteria serve as an important line of defense against colonisation by opportunisitic pathogens, but the underlying molecular mechanisms remain poorly explored. Here, we show that strains of a commensal bacterium, Haemophilus haemolyticus, make hemophilin, a heme-binding protein that inhibits growth of the opportunistic pathogen, non-typeable Haemophilus influenzae (NTHi) in culture. We purified the NTHi-inhibitory protein from H. haemolyticus and identified the hemophilin gene using p ...[more]