Extracellular vesicles impose quiescence and confer DNA-damage on residual HSC in the AML niche
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ABSTRACT: To understand the mechanism by which AML-EVs may enforce quiescence, we performed tandem mass tag (TMT) proteomic profiling of in vitro cultured c-Kit+ hematopoietic stem and progenitor cells (HSPC) (to obtain the minimum required amount of protein lysates) treated with extracellular vesicles (EVs) for 48 hours from human HL-60 or Molm-14 cell cultures versus controls.
INSTRUMENT(S): Orbitrap Fusion ETD
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Hematopoietic Stem Cell, Bone Marrow
DISEASE(S): Acute Leukemia
SUBMITTER: Phillip Wilmarth
LAB HEAD: Dr. Peter Kurre
PROVIDER: PXD013688 | Pride | 2019-06-24
REPOSITORIES: Pride
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