Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Petra Beli
LAB HEAD: Petra Beli
PROVIDER: PXD013719 | Pride | 2020-01-29
REPOSITORIES: Pride
Bekbulat Fazilet F Schmitt Daniel D Feldmann Anne A Huesmann Heike H Eimer Stefan S Juretschke Thomas T Beli Petra P Behl Christian C Kern Andreas A
Journal of molecular biology 20191224 4
Autophagy is dependent on appropriate lipid supply for autophagosome formation. The regulation of lipid acquisition and the autophagy network response to lipid-limiting conditions are mostly elusive. Here, we show that the knockout of the RAB GTPase RAB18 interferes with lipid droplet catabolism, causing an impaired fatty acid release. The resulting reduced lipid-droplet-derived lipid availability influences autophagy and provokes adaptive modifications of the autophagy network. These adjustment ...[more]