Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Michael Kreutzer
LAB HEAD: Prof. Dr. Michael O. Glocker
PROVIDER: PXD013823 | Pride | 2019-06-03
REPOSITORIES: Pride
Danquah Bright D BD Röwer Claudia C Opuni KwabenaF M KM El-Kased Reham R Frommholz David D Illges Harald H Koy Cornelia C Glocker Michael O MO
Molecular & cellular proteomics : MCP 20190530 8
Epitope mapping, which is the identification of antigenic determinants, is essential for the design of novel antibody-based therapeutics and diagnostic tools. ITEM-THREE is a mass spectrometry-based epitope mapping method that can identify epitopes on antigens upon generating an immune complex in electrospray-compatible solutions by adding an antibody of interest to a mixture of peptides from which at least one holds the antibody's epitope. This mixture is nano-electrosprayed without purificatio ...[more]