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Interacting partners of Rac1 (P29S/Q61L) compared to constitutively active Rac1 (Q61L)

ABSTRACT: Interactors of double mutant Rac1 (P29S/Q61L) compared to constitutively active Rac1 (Q61L).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Chlorocebus Sabaeus

TISSUE(S): Fibroblast, Cell Line Cell

DISEASE(S): Disease Free

SUBMITTER: Sergio Lilla

LAB HEAD: Sara Rossana Zanivan

PROVIDER: PXD013941 | Pride | 2019-11-12

REPOSITORIES: Pride

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CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors.

Whitelaw Jamie A JA Lilla Sergio S Paul Nikki R NR Fort Loic L Zanivan Sara S Machesky Laura M LM

Communicative & integrative biology 20190723 1

Fam49 proteins, now referred to as CYRI (CYFIP-related Rac Interactor), are evolutionarily conserved across many phyla. Their closest relative by amino acid sequence is CYFIP, as both proteins contain a domain of unknown function DUF1394. We recently showed that CYRI and the DUF1394 can mediate binding to Rac1 and evidence is building to suggest that CYRI plays important roles in cell migration, chemotaxis and pathogen entry into cells. Here we discuss how CYRI proteins fit into the current fram ...[more]

PMID: 31413787

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Local GTP availability is an essential step in regulation of RAC1 activity and cell invasion

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