Quantitative proteomics and phosphoproteomics reveal that PIM3 modulates cell migration via regulating Rho GTPase signaling
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Na Jiang
LAB HEAD: ruibing chen
PROVIDER: PXD014044 | Pride | 2020-02-04
REPOSITORIES: Pride
Publications
Proto-Oncogene Serine/Threonine Kinase PIM3 Promotes Cell Migration via Modulating Rho GTPase Signaling.
Dang Yamei Y Jiang Na N Wang Hao H Chen Xuechun X Gao Yan Y Zhang Xiangyang X Qin Guoxuan G Li Yongmei Y Chen Ruibing R
Journal of proteome research 20200207 3
The proto-oncogene serine/threonine-protein kinase PIM3 plays critical roles in cancer, and it has been extensively exploited as a drug target. Here, we investigated the quantitative changes in the cellular proteome and phosphoproteome in liver cancer cells overexpressing PIM3 to obtain a better understanding of the regulatory functions of PIM3 and the underlying molecular mechanisms. This work depicted the landscape of gene expression and protein phosphorylation potentially regulated by PIM3. A ...[more]
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