Dataset Information
Quantitative proteomics of Col and AtPABs mutant
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress)
TISSUE(S): Whole Body
SUBMITTER: 
Qing Huan
LAB HEAD: Wenfeng Qian
PROVIDER: PXD014071 | Pride | 2019-10-11
REPOSITORIES: Pride
Publications
Impact of poly(A)-tail G-content on Arabidopsis PAB binding and their role in enhancing translational efficiency.
Genome biology 20190903 1
<h4>Background</h4>Polyadenylation plays a key role in producing mature mRNAs in eukaryotes. It is widely believed that the poly(A)-binding proteins (PABs) uniformly bind to poly(A)-tailed mRNAs, regulating their stability and translational efficiency.<h4>Results</h4>We observe that the homozygous triple mutant of broadly expressed Arabidopsis thaliana PABs, AtPAB2, AtPAB4, and AtPAB8, is embryonic lethal. To understand the molecular basis, we characterize the RNA-binding landscape of these PABs ...[more]
