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Deng Lab RRM2 Acetylation Study

ABSTRACT: RRM2 Acetylation Mass Spectrometry Data including PD result files, raw mass spectrometry data and curated results.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Duc Duong

LAB HEAD: Xingming Deng

PROVIDER: PXD014105 | Pride | 2019-07-18

REPOSITORIES: Pride

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Publications

Acetylation regulates ribonucleotide reductase activity and cancer cell growth.

Chen Guo G Luo Yin Y Warncke Kurt K Sun Youwei Y Yu David S DS Fu Haian H Behera Madhusmita M Ramalingam Suresh S SS Doetsch Paul W PW Duong Duc M DM Lammers Michael M Curran Walter J WJ Deng Xingming X

Nature communications 20190719 1

Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates (dNDPs) to provide dNTP precursors for DNA synthesis. Here, we report that acetylation and deacetylation of the RRM2 subunit of RNR acts as a molecular switch that impacts RNR activity, dNTP synthesis, and DNA replication fork progression. Acetylation of RRM2 at K95 abrogates RNR activity by disrupting its homodimer assembly. RRM2 is directly acetylated by KAT7, and deacetylated by Sirt2, respectiv ...[more]

PMID: 31324785

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