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Trypanosoma brucei global proteome changes upon suramin exposure

ABSTRACT: To understand how suramin kills Trypanosoma brucei, we examined the impact on proteome at different timepoints

INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive

ORGANISM(S): Trypanosoma Brucei

TISSUE(S): Permanent Cell Line Cell

DISEASE(S): Sleeping Sickness

SUBMITTER: Martin Zoltner

LAB HEAD: Mark C. Field

PROVIDER: PXD014215 | Pride | 2020-04-30

REPOSITORIES: Pride

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Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes.

Zoltner Martin M Campagnaro Gustavo D GD Taleva Gergana G Burrell Alana A Cerone Michela M Leung Ka-Fai KF Achcar Fiona F Horn David D Vaughan Sue S Gadelha Catarina C Zíková Alena A Barrett Michael P MP de Koning Harry P HP Field Mark C MC

The Journal of biological chemistry 20200430 24

Introduced about a century ago, suramin remains a frontline drug for the management of early-stage East African trypanosomiasis (sleeping sickness). Cellular entry into the causative agent, the protozoan parasite <i>Trypanosoma brucei</i>, occurs through receptor-mediated endocytosis involving the parasite's invariant surface glycoprotein 75 (ISG75), followed by transport into the cytosol via a lysosomal transporter. The molecular basis of the trypanocidal activity of suramin remains unclear, bu ...[more]

PMID: 32354742

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