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Proteomics analysis of muscles from long lived O1/O3 flies in young and old age (Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations) Liam C. Hunt, Jianqin Jiao, Yong-Dong Wang, David Finkelstein, Deepti Rao, Michelle Curley, Maricela Robles-Murguia, Abbas Shirinifard, Vishwajeeth R. Pagala, Junmin Peng, Yiping Fan, and Fabio Demontis. Genome Research In press 2019.

ABSTRACT: Protein expression profiles in the whole tissue lysate extracted from the thorax of O1 and O3 long-lived flies with the control B3 strain flies and analyzed by tandem mass tag (TMT)–based mass spectrometry.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Aorta Thoracica Smooth Muscle

SUBMITTER: Vishwajeeth Pagala

LAB HEAD: Fabio Demontis

PROVIDER: PXD014223 | Pride | 2019-06-13

REPOSITORIES: Pride

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Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across <i>Drosophila</i> populations.

Hunt Liam C LC Jiao Jianqin J Wang Yong-Dong YD Finkelstein David D Rao Deepti D Curley Michelle M Robles-Murguia Maricela M Shirinifard Abbas A Pagala Vishwajeeth R VR Peng Junmin J Fan Yiping Y Demontis Fabio F

Genome research 20190627 8

Organisms use endogenous clocks to adapt to the rhythmicity of the environment and to synchronize social activities. Although the circadian cycle is implicated in aging, it is unknown whether natural variation in its function contributes to differences in lifespan between populations and whether the circadian clock of specific tissues is key for longevity. We have sequenced the genomes of <i>Drosophila melanogaster</i> strains with exceptional longevity that were obtained via multiple rounds of ...[more]

PMID: 31249065

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Publications

Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across <i>Drosophila</i> populations.

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