Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Epithelial Cell, Small Intestine Epithelium
SUBMITTER: Alessandro Ori
LAB HEAD: Alessandro Ori
PROVIDER: PXD014311 | Pride | 2020-04-29
REPOSITORIES: Pride
Gebert Nadja N Cheng Chia-Wei CW Kirkpatrick Joanna M JM Di Fraia Domenico D Yun Jina J Schädel Patrick P Pace Simona S Garside George B GB Werz Oliver O Rudolph K Lenhard KL Jasper Henri H Yilmaz Ömer H ÖH Ori Alessandro A
Cell reports 20200401 4
The small intestine is responsible for nutrient absorption and one of the most important interfaces between the environment and the body. During aging, changes of the epithelium lead to food malabsorption and reduced barrier function, thus increasing disease risk. The drivers of these alterations remain poorly understood. Here, we compare the proteomes of intestinal crypts from mice across different anatomical regions and ages. We find that aging alters epithelial immunity, metabolism, and cell ...[more]