Proteomics

Dataset Information

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Sperm-specific proteins and cancer testis antigens exist outside the blood-testis barrier

ABSTRACT: Sperm develop in the seminiferous tubules of the testis from puberty, sequestered inside the blood-testis barrier to prevent their recognition as “non-self” by the immune system. It is widely assumed that proteins expressed specifically in sperm do not have direct access to the circulation or the immune system. This assumption underlies the pursuit of cancer testis antigens (CTAs) as therapeutic targets and biomarkers for particular cancers. CTAs are aberrantly expressed in cancer but only expressed in sperm in healthy men; thus these proteins are assumed to be absent from the blood and/or to be neoantigens.

INSTRUMENT(S): impact II

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Testis, Interstitial Fluid

SUBMITTER: Laura Dagley  

LAB HEAD: Peter Stanton

PROVIDER: PXD014333 | Pride | 2021-04-01

REPOSITORIES: Pride

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Publications

Sperm proteins and cancer-testis antigens are released by the seminiferous tubules in mice and men.

O'Donnell Liza L   Rebourcet Diane D   Dagley Laura F LF   Sgaier Raouda R   Infusini Giuseppe G   O'Shaughnessy Peter J PJ   Chalmel Frederic F   Fietz Daniela D   Weidner Wolfgang W   Legrand Julien M D JMD   Hobbs Robin M RM   McLachlan Robert I RI   Webb Andrew I AI   Pilatz Adrian A   Diemer Thorsten T   Smith Lee B LB   Stanton Peter G PG  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20210301 3

Sperm develop from puberty in the seminiferous tubules, inside the blood-testis barrier to prevent their recognition as "non-self" by the immune system, and it is widely assumed that human sperm-specific proteins cannot access the circulatory or immune systems. Sperm-specific proteins aberrantly expressed in cancer, known as cancer-testis antigens (CTAs), are often pursued as cancer biomarkers and therapeutic targets based on the assumption they are neoantigens absent from the circulation in hea  ...[more]

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