Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, LTQ Orbitrap Elite, Q Exactive
ORGANISM(S): Homo Sapiens (human) Legionella Pneumophila Subsp. Pneumophila (strain Philadelphia 1 / Atcc 33152 / Dsm 7513)
TISSUE(S): Permanent Cell Line Cell, Kidney
SUBMITTER: Florian Bonn
LAB HEAD: Ivan Dikic
PROVIDER: PXD014362 | Pride | 2019-07-16
REPOSITORIES: Pride
Nature 20190722 7769
The family of bacterial SidE enzymes catalyses phosphoribosyl-linked serine ubiquitination and promotes infectivity of Legionella pneumophila, a pathogenic bacteria that causes Legionnaires' disease<sup>1-3</sup>. SidE enzymes share the genetic locus with the Legionella effector SidJ that spatiotemporally opposes the toxicity of these enzymes in yeast and mammalian cells, through a mechanism that is currently unknown<sup>4-6</sup>. Deletion of SidJ leads to a substantial defect in the growth of ...[more]