Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

ABSTRACT: To date few DDK substrates other than the MCM helicase have been identified, and none are implicated in fork protection or restart. Here we searched for such factors, using SILAC and quantitative mass spectrometry to identify the DDK phosphoproteome during fork stalling.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Retinal Pigment Epithelium Cell

SUBMITTER: Stephanie Munk  

LAB HEAD: Prasad Jallepalli

PROVIDER: PXD014399 | Pride | 2021-06-29

REPOSITORIES: Pride