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Pathophysiology of arterial cardiovascular events in patients with JAK2V617F myeloproliferative neoplasms

ABSTRACT: Cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms. Their mechanisms are poorly understood. To investigate the role of microvesicles in these events, we performed a proteomic analysis of microvesicles derived from red blood cells from mice with a myeloproliferative neoplasms (Jak2V617F Flex/WT ;VE-cadherin-Cre) vs. littermate controls.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Plasma, Extracellular Vesicle

SUBMITTER: Valentin SABATET

LAB HEAD: Damarys Loew

PROVIDER: PXD014451 | Pride | 2020-02-17

REPOSITORIES: Pride

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Erythrocyte-derived microvesicles induce arterial spasms in JAK2V617F myeloproliferative neoplasm.

Poisson Johanne J Tanguy Marion M Davy Hortense H Camara Fatoumata F El Mdawar Marie-Belle MB Kheloufi Marouane M Dagher Tracy T Devue Cécile C Lasselin Juliette J Plessier Aurélie A Merchant Salma S Blanc-Brude Olivier O Souyri Michèle M Mougenot Nathalie N Dingli Florent F Loew Damarys D Hatem Stephane N SN James Chloé C Villeval Jean-Luc JL Boulanger Chantal M CM Rautou Pierre-Emmanuel PE

The Journal of clinical investigation 20200501 5

Arterial cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms (MPNs). However, their mechanisms are poorly understood. The high prevalence of myocardial infarction without significant coronary stenosis or atherosclerosis in patients with MPNs suggests that vascular function is altered. The consequences of JAK2V617F mutation on vascular reactivity are unknown. We observe here increased responses to vasoconstrictors in arteries from Jak2V617F ...[more]

PMID: 32045382

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