Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
TISSUE(S): Ovary
SUBMITTER: Emma Kneuss
LAB HEAD: Gregory J. Hannon
PROVIDER: PXD014472 | Pride | 2019-07-29
REPOSITORIES: Pride
Kneuss Emma E Munafò Marzia M Eastwood Evelyn L EL Deumer Undine-Sophie US Preall Jonathan B JB Hannon Gregory J GJ Czech Benjamin B
Genes & development 20190815 17-18
The PIWI-interacting RNA (piRNA) pathway is a conserved small RNA-based immune system that protects animal germ cell genomes from the harmful effects of transposon mobilization. In <i>Drosophila</i> ovaries, most piRNAs originate from dual-strand clusters, which generate piRNAs from both genomic strands. Dual-strand clusters use noncanonical transcription mechanisms. Although transcribed by RNA polymerase II, cluster transcripts lack splicing signatures and poly(A) tails. mRNA processing is impo ...[more]