Dataset Information
Thermal proteome profiling of anti-HEV compound
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human) Hepatitis E Virus Type 1
SUBMITTER: 
Andre Mateus
LAB HEAD: Alexander Ploss
PROVIDER: PXD014485 | Pride | 2021-01-04
REPOSITORIES: Pride
Publications
Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90.
Antiviral research 20201214
Hepatitis E virus (HEV) causes 14 million infections and 60,000 deaths per year globally, with immunocompromised persons and pregnant women experiencing severe symptoms. Although ribavirin can be used to treat chronic hepatitis E, toxicity in pregnant patients and the emergence of resistant strains are major concerns. Therefore there is an imminent need for effective HEV antiviral agents. The aims of this study were to develop a drug screening platform and to discover novel approaches to targeti ...[more]
