Proteomics

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Data in support of Prenatal intra-amniotic lipopolysaccharide induces neonatal renal immune activation after preterm birth

ABSTRACT: Preterm birth is often predisposed by chorioamnionitis (CA) and CA affects the fetal gut and lungs via intra-amniotic (IA) inflammation, thus accentuating the proinflammatory effects of preterm birth. It is not known if IA inflammation also affects other perfusion-sensitive organs (e.g., kidneys) before and after preterm birth. Using preterm pigs as model for preterm infants, we hypothesized that CA induces fetal and neonatal renal dysfunctions that can intially be detected via plasma proteome, partly explaining the frequent renal dysfunction in preterm infants. Fetal pigs (88% gestation) were given an IA dose of lipopolysaccharide (LPS, 1 mg/kg, n=28), delivered preterm by cesarean section three days later, and compared with controls (CON, n=26) at birth and postnatal day five. Plasma proteome and protein markers of inflammatory pathways were evaluated.

INSTRUMENT(S):

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Blood Plasma

SUBMITTER: Allan Stensballe  

LAB HEAD: Laboratory for Medical Mass spectrometry

PROVIDER: PXD014619 | Pride | 2021-03-25

REPOSITORIES: Pride

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MaxQuanttxt_txt.zip Other
ProteomXchangeIDcodes.xlsx Xlsx
analysis01.baf Other
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Publications

Use of a gum elastic bougie in a cat with severe upper airway stenosis.

Kato Keiko K   Itami Takaharu T   Torisu Shidow S   Sakai Toshikazu T   Yamashita Kazuto K  

Open veterinary journal 20230123 1

<h4>Background</h4>Gum elastic bougie (GEB) is an airway management device for patients who are difficult to intubate and its use has been reported in human medicine. However, to our knowledge, no reports in veterinary medicine have described oxygenation using GEB. We describe a case in which GEB was used to maintain oxygenation in a cat with severe upper airway stenosis.<h4>Case description</h4>A 10-year-old neutered male domestic shorthair cat was diagnosed with a laryngeal tumor with severe u  ...[more]