Listeria monocytogenes exploits the MICOS complex subunit Mic10 to promote mitochondrial fragmentation and cellular infection
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Hct-116 Cell
SUBMITTER: 
Thibaut Douché
LAB HEAD: Pascale Cossart
PROVIDER: PXD014667 | Pride | 2020-02-17
REPOSITORIES: Pride
Publications
Listeria monocytogenes Exploits Mitochondrial Contact Site and Cristae Organizing System Complex Subunit Mic10 To Promote Mitochondrial Fragmentation and Cellular Infection.
Carvalho Filipe F Spier Anna A Chaze Thibault T Matondo Mariette M Cossart Pascale P Stavru Fabrizia F
mBio 20200204 1
Mitochondrial function adapts to cellular demands and is affected by the ability of the organelle to undergo fusion and fission in response to physiological and nonphysiological cues. We previously showed that infection with the human bacterial pathogen <i>Listeria monocytogenes</i> elicits transient mitochondrial fission and a drop in mitochondrion-dependent energy production through a mechanism requiring the bacterial pore-forming toxin listeriolysin O (LLO). Here, we performed quantitative mi ...[more]
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