PALB2 ChAM acetylation mapping in human cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Marjorie Fournier
LAB HEAD: Fumiko Esashi
PROVIDER: PXD014678 | Pride | 2023-03-10
REPOSITORIES: Pride
Publications
KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity.
Fournier Marjorie M Rodrigue Amélie A Milano Larissa L Bleuyard Jean-Yves JY Couturier Anthony M AM Wall Jacob J Ellins Jessica J Hester Svenja S Smerdon Stephen J SJ Tora László L Masson Jean-Yves JY Esashi Fumiko F
eLife 20221021
The tumour suppressor PALB2 stimulates RAD51-mediated homologous recombination (HR) repair of DNA damage, whilst its steady-state association with active genes protects these loci from replication stress. Here, we report that the lysine acetyltransferases 2A and 2B (KAT2A/2B, also called GCN5/PCAF), two well-known transcriptional regulators, acetylate a cluster of seven lysine residues (7K-patch) within the PALB2 chromatin association motif (ChAM) and, in this way, regulate context-dependent PAL ...[more]
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