IFITM3-mediated regulation of cell membrane dynamics is essential for malignant B-cell transformation

ABSTRACT: B cell receptor (BCR) signaling and oncogenic tyrosine kinases that mimic BCR-signaling in B-lineage leukemia and lymphoma depend on assembly of membrane proximal signaling complexes. Signalosomes in normal BCR- and oncogene (e.g. BCR-ABL1, RAS-pathway lesions) signal transduction are recruited to phospholipid anchors in lipid rafts. The robustness of these complexes depends on cholesterol accumulation in lipid rafts. Here we identified the interferon-induced transmembrane protein IFITM3 as a central regulator of cholesterol in lipid rafts.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): B Cell, Primary Cell, Cell Suspension Culture

DISEASE(S): Acute Leukemia

SUBMITTER: Matthew Nix  

LAB HEAD: Arun Wiita

PROVIDER: PXD014691 | Pride | 2020-12-18

REPOSITORIES: Pride