Pharmacological induction of selective endoplasmic reticulum retention as a novel strategy for cancer therapy

ABSTRACT: We analysed the difference in the surface proteome of human cells that were either subjected to ER stress (induced by thapsigargin (Tg)) only or were additionally treated with a pharmacological inhibitor against the eIF2α kinase PERK, which is localized in the endoplasmic reticulum. Compared to single ER stress, several important plasma-membrane associated kinases, showed a significant downregulation under PERK inhibition.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver, Permanent Cell Line Cell

DISEASE(S): Hepatocellular Carcinoma

SUBMITTER: Christian Preisinger  

LAB HEAD: Boaz Tirosh

PROVIDER: PXD014709 | Pride | 2020-03-02

REPOSITORIES: Pride