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Salivary proteome signatures in the early and middle stages of human pregnancy with term birth outcome

ABSTRACT: This prospective study is to find changes in salivary protein expressions from first to early third trimester of pregnancy in normal term birth using SWATH-MS strategy. Saliva at three periods of gestation, 6-13 (V1), 18-21(V2), and 26-29 (V3) weeks from 20 singleton pregnant women were used in a discovery phase. Selected proteins from the discovery study were verified by targeted schedule-MRM (multiple reaction monitoring) experiments in a separate subset of subjects (N=14). Using in-house generated saliva-specific protein library, 65 proteins (q-value<0.1) changed as a function of gestational age.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Saliva

SUBMITTER: Bhoj Kumar

LAB HEAD: Tushar Kanti Maiti

PROVIDER: PXD014800 | Pride | 2020-09-28

REPOSITORIES: Pride

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Salivary proteome signatures in the early and middle stages of human pregnancy with term birth outcome.

Dey Amit Kumar AK Kumar Bhoj B Singh Abhishek Kumar AK Ranjan Prakash P Thiruvengadam Ramachandran R Desiraju Bapu Koundinya BK Kshetrapal Pallavi P Wadhwa Nitya N Bhatnagar Shinjini S Rashid Faraz F Malakar Dipankar D Salunke Dinakar M DM Maiti Tushar Kanti TK

Scientific reports 20200515 1

The establishment and maintenance of pregnancy in humans proceed through a continuous change of biochemical and biophysical processes. It requires a constant interaction between the fetus and the maternal system. The present prospective study aims to elucidate changes in salivary proteome from the early to middle stages of term pregnancy, and establishing an expressional trajectory for modulated proteins. To date, a comprehensive characterization of the longitudinal salivary proteome in pregnanc ...[more]

PMID: 32415095

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