Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Epithelial Cell, Kidney
DISEASE(S): Polycystic Kidney
SUBMITTER: Nicolas Kuperwasser
LAB HEAD: Mario Pende
PROVIDER: PXD014832 | Pride | 2020-08-11
REPOSITORIES: Pride
Bonucci Martina M Kuperwasser Nicolas N Barbe Serena S Koka Vonda V de Villeneuve Delphine D Zhang Chi C Srivastava Nishit N Jia Xiaoying X Stokes Matthew P MP Bienaimé Frank F Verkarre Virginie V Lopez Jean Baptiste JB Jaulin Fanny F Pontoglio Marco M Terzi Fabiola F Delaval Benedicte B Piel Matthieu M Pende Mario M
Nature communications 20200624 1
mTOR activation is essential and sufficient to cause polycystic kidneys in Tuberous Sclerosis Complex (TSC) and other genetic disorders. In disease models, a sharp increase of proliferation and cyst formation correlates with a dramatic loss of oriented cell division (OCD). We find that OCD distortion is intrinsically due to S6 kinase 1 (S6K1) activation. The concomitant loss of S6K1 in Tsc1-mutant mice restores OCD but does not decrease hyperproliferation, leading to non-cystic harmonious hyper ...[more]