Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
SUBMITTER: Ignasi Forne
LAB HEAD: Prof. Dr. Alexander Brehm
PROVIDER: PXD014857 | Pride | 2019-11-11
REPOSITORIES: Pride
Mačinković Igor I Theofel Ina I Hundertmark Tim T Kovač Kristina K Awe Stephan S Lenz Jonathan J Forné Ignasi I Lamp Boris B Nist Andrea A Imhof Axel A Stiewe Thorsten T Renkawitz-Pohl Renate R Rathke Christina C Brehm Alexander A
Nucleic acids research 20191201 22
CoREST has been identified as a subunit of several protein complexes that generate transcriptionally repressive chromatin structures during development. However, a comprehensive analysis of the CoREST interactome has not been carried out. We use proteomic approaches to define the interactomes of two dCoREST isoforms, dCoREST-L and dCoREST-M, in Drosophila. We identify three distinct histone deacetylase complexes built around a common dCoREST/dRPD3 core: A dLSD1/dCoREST complex, the LINT complex ...[more]