Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Keratinocyte, Skin
DISEASE(S): Eczema
SUBMITTER: Sara ten Have
LAB HEAD: Sara Brown
PROVIDER: PXD014875 | Pride | 2019-08-14
REPOSITORIES: Pride
Wellcome open research 20191126
<b>Background:</b> Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin ( <i>FLG</i>) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency leads to atopic inflammation remain incompletely understood. Skin as an organ that can be modelled using primary cells <i>in vitro</i> provides the opportunity for selected genetic effects to be investigated in detail. <b>Methods:</b> P ...[more]