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Proteomic responses of Candida glabrata to acetate as the sole carbon source

ABSTRACT: The responses of Candida glabrata grown in acetate-containing growth medium was investigated by label-free quantitative proteomic analysis using the liquid chromatography–mass spectrometry.

INSTRUMENT(S): Q Exactive

ORGANISM(S): [candida] Glabrata Cbs 138

DISEASE(S): Candidiasis

SUBMITTER: Leslie Than

LAB HEAD: Leslie Thian Lung Than

PROVIDER: PXD014916 | Pride | 2021-01-08

REPOSITORIES: Pride

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Transcriptomic and proteomic profiling revealed reprogramming of carbon metabolism in acetate-grown human pathogen Candida glabrata.

Chew Shu Yih SY Brown Alistair J P AJP Lau Benjamin Yii Chung BYC Cheah Yoke Kqueen YK Ho Kok Lian KL Sandai Doblin D Yahaya Hassan H Than Leslie Thian Lung LTL

Journal of biomedical science 20210102 1

<h4>Background</h4>Emergence of Candida glabrata, which causes potential life-threatening invasive candidiasis, has been widely associated with high morbidity and mortality. In order to cause disease in vivo, a robust and highly efficient metabolic adaptation is crucial for the survival of this fungal pathogen in human host. In fact, reprogramming of the carbon metabolism is believed to be indispensable for phagocytosed C. glabrata within glucose deprivation condition during infection.<h4>Method ...[more]

PMID: 33388061

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