Ontology highlight
ABSTRACT:
INSTRUMENT(S): AB SCIEX instrument model
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B-cell Lymphoma Cell, Lymph Node
DISEASE(S): Lymphoma
SUBMITTER: Peter Blattmann
LAB HEAD: Ruedi Aebersold
PROVIDER: PXD014943 | Pride | 2019-10-07
REPOSITORIES: Pride
Molecular oncology 20190918 11
Formalin-fixed, paraffin-embedded (FFPE), biobanked tissue samples offer an invaluable resource for clinical and biomarker research. Here, we developed a pressure cycling technology (PCT)-SWATH mass spectrometry workflow to analyze FFPE tissue proteomes and applied it to the stratification of prostate cancer (PCa) and diffuse large B-cell lymphoma (DLBCL) samples. We show that the proteome patterns of FFPE PCa tissue samples and their analogous fresh-frozen (FF) counterparts have a high degree o ...[more]