Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion ETD
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Egor Vorontsov
LAB HEAD: Jens Nielsen
PROVIDER: PXD014962 | Pride | 2020-03-13
REPOSITORIES: Pride
Nature communications 20200420 1
Cells maintain reserves in their metabolic and translational capacities as a strategy to quickly respond to changing environments. Here we quantify these reserves by stepwise reducing nitrogen availability in yeast steady-state chemostat cultures, imposing severe restrictions on total cellular protein and transcript content. Combining multi-omics analysis with metabolic modeling, we find that seven metabolic superpathways maintain >50% metabolic capacity in reserve, with glucose metabolism maint ...[more]