Dataset Information
Immunopeptidome of an acute myeloid leukemia cell line THP1
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Suspension Culture, Monocyte
DISEASE(S): Acute Leukemia
SUBMITTER: 
Kirti Pandey
LAB HEAD: Anthony Wayne Purcell
PROVIDER: PXD015039 | Pride | 2020-05-13
REPOSITORIES: Pride
Publications
In-depth mining of the immunopeptidome of an acute myeloid leukemia cell line using complementary ligand enrichment and data acquisition strategies.
Molecular immunology 20200505
The identification of T cell epitopes derived from tumour specific antigens remains a significant challenge for the development of peptide-based vaccines and immunotherapies. The use of mass spectrometry-based approaches (immunopeptidomics) can provide powerful new avenues for the identification of such epitopes. In this study we report the use of complementary peptide antigen enrichment methods and a comprehensive mass spectrometric acquisition strategy to provide in-depth immunopeptidome data ...[more]
