Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
SUBMITTER: Alberto Valdés
LAB HEAD: María Luisa Marina
PROVIDER: PXD015102 | Pride | 2021-09-08
REPOSITORIES: Pride
Valdés Alberto A Castro-Puyana María M García-Pastor Coral C Lucio-Cazaña Francisco J FJ Marina María Luisa ML
PloS one 20200624 6
During diabetes, renal proximal tubular cells (PTC) are exposed to a combination of high glucose and hypoxic conditions, which plays a relevant role in the development of diabetic kidney disease (DKD). In this work, a time-series proteomic study was performed to analyse the effect of a diabetic-like microenvironment induced changes on HK-2 cells, a human cell line derived from normal proximal tubular epithelial cells. Cells simultaneously exposed to high glucose (25 mM) and hypoxia (1% O2) were ...[more]