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Human brain global proteome and succinylome analyses

ABSTRACT: This is about the global proteome and global succinylome of human brain tissues.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Neutrophil

SUBMITTER: Sheng Zhang

LAB HEAD: Sheng Zhang

PROVIDER: PXD015124 | Pride | 2021-12-08

REPOSITORIES: Pride

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The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease.

Sun Lidan L Bhawal Ruchika R Xu Hui H Chen Huanlian H Anderson Elizabeth T ET Haroutunian Vahrum V Cross Abigail C AC Zhang Sheng S Gibson Gary E GE

Journal of neurochemistry 20210512 2

Metabolic changes that correlate to cognitive changes are well-known in Alzheimer's disease (AD). Metabolism is often linked to functional changes in proteins by post-translational modifications. The importance of the regulation of transcription by acetylation is well documented. Advanced mass spectrometry reveals hundreds of acetylated proteins in multiple tissues, but the acetylome of human brain, its functional significance, and the changes with disease are unknown. Filling this gap is critic ...[more]

PMID: 33905124

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