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HPLC-MS/MS analysis of plasma samples from patients with colorectal cancer

ABSTRACT: We sought to identify a characteristic profile of proteins in blood plasma samples taken from patients with colorectal cancer using mass spectrometry. We obtained mass spectrometry data of 38 samples from patients with colorectal cancer and 41 samples from healthy volunteers and the data analysis were carried out using panoramic ultra-high resolution mass spectrometry. We carried out a comparative analysis for two series "case" and "control" of protein profiles, differently expressed proteins and proteins with posttranslational modifications.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Colon Cancer

SUBMITTER: Anna Kaysheva

LAB HEAD: Anna Kaysheva

PROVIDER: PXD015163 | Pride | 2020-04-02

REPOSITORIES: Pride

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Revelation of Proteomic Indicators for Colorectal Cancer in Initial Stages of Development.

Kopylov Arthur T AT Stepanov Alexander A AA Malsagova Kristina A KA Soni Deepesh D Kushlinsky Nikolay E NE Enikeev Dmitry V DV Potoldykova Natalia V NV Lisitsa Andrey V AV Kaysheva Anna L AL

Molecules (Basel, Switzerland) 20200131 3

<b>Background:</b> Colorectal cancer (CRC) at a current clinical level is still hardly diagnosed, especially with regard to nascent tumors, which are typically asymptotic. Searching for reliable biomarkers of early diagnosis is an extremely essential task. Identification of specific post-translational modifications (PTM) may also significantly improve net benefits and tailor the process of CRC recognition. We examined depleted plasma samples obtained from 41 healthy volunteers and 28 patients wi ...[more]

PMID: 32023884

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