Lysine acetylation of the housekeeping sigma factor enhances the activity of RNA polymerase holoenzyme
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Streptomyces Venezuelae
SUBMITTER: 
Ji-Eun Kim
LAB HEAD: Jung-Hye Roe
PROVIDER: PXD015174 | Pride | 2020-05-27
REPOSITORIES: Pride
Publications
Lysine acetylation of the housekeeping sigma factor enhances the activity of the RNA polymerase holoenzyme.
Kim Ji-Eun JE Choi Joon-Sun JS Kim Jong-Seo JS Cho You-Hee YH Roe Jung-Hye JH
Nucleic acids research 20200301 5
Protein lysine acetylation, one of the most abundant post-translational modifications in eukaryotes, occurs in prokaryotes as well. Despite the evidence of lysine acetylation in bacterial RNA polymerases (RNAPs), its function remains unknown. We found that the housekeeping sigma factor (HrdB) was acetylated throughout the growth of an actinobacterium, Streptomyces venezuelae, and the acetylated HrdB was enriched in the RNAP holoenzyme complex. The lysine (K259) located between 1.2 and 2 regions ...[more]
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