Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
SUBMITTER: John Coan
LAB HEAD: Katrin Chua
PROVIDER: PXD015233 | Pride | 2019-10-02
REPOSITORIES: Pride
Li Tie-Mei TM Coan John P JP Krajewski Krzysztof K Zhang Lichao L Elias Joshua E JE Strahl Brian D BD Gozani Or O Chua Katrin F KF
Scientific reports 20191002 1
Covalent post-translational modification (PTM) of proteins with acyl groups of various carbon chain-lengths regulates diverse biological processes ranging from chromatin dynamics to subcellular localization. While the YEATS domain has been found to be a prominent reader of acetylation and other short acyl modifications, whether additional acyl-lysine reader domains exist, particularly for longer carbon chains, is unclear. Here, we employed a quantitative proteomic approach using various modified ...[more]