Proteomics

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Proteomics analysis of Normothermic Ex-Vivo perfusion in a DCD auto-transplantation model

ABSTRACT: We performed an unbiased proteomics analysis of 28 kidney biopsies obtained at three time points from pig kidneys subjected to 30-minutes of warm ischemia, followed by 8 hours of NEVKP or static cold storage (SCS), and auto-transplantation.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Kidney

SUBMITTER: Caitriona McEvoy  

LAB HEAD: Ana Konvalinka

PROVIDER: PXD015277 | Pride | 2021-06-23

REPOSITORIES: Pride

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Publications

Normothermic Ex-vivo Kidney Perfusion in a Porcine Auto-Transplantation Model Preserves the Expression of Key Mitochondrial Proteins: An Unbiased Proteomics Analysis.

McEvoy Caitriona M CM   Clotet-Freixas Sergi S   Tokar Tomas T   Pastrello Chiara C   Reid Shelby S   Batruch Ihor I   RaoPeters Adrien A E AAE   Kaths J Moritz JM   Urbanellis Peter P   Farkona Sofia S   Van Julie A D JAD   Urquhart Bradley L BL   John Rohan R   Jurisica Igor I   Robinson Lisa A LA   Selzner Markus M   Konvalinka Ana A  

Molecular & cellular proteomics : MCP 20210523

Normothermic ex-vivo kidney perfusion (NEVKP) results in significantly improved graft function in porcine auto-transplant models of donation after circulatory death injury compared with static cold storage (SCS); however, the molecular mechanisms underlying these beneficial effects remain unclear. We performed an unbiased proteomics analysis of 28 kidney biopsies obtained at three time points from pig kidneys subjected to 30 min of warm ischemia, followed by 8 h of NEVKP or SCS, and auto-transpl  ...[more]

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