Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Xenopus Laevis (african Clawed Frog)
TISSUE(S): Egg Cell, Egg, Sperm
SUBMITTER: Akinori Endo
LAB HEAD: Atsuya Nishiyama
PROVIDER: PXD015282 | Pride | 2020-02-25
REPOSITORIES: Pride
Nature communications 20200306 1
Stable inheritance of DNA methylation is critical for maintaining differentiated phenotypes in multicellular organisms. We have recently identified dual mono-ubiquitylation of histone H3 (H3Ub2) by UHRF1 as an essential mechanism to recruit DNMT1 to chromatin. Here, we show that PCNA-associated factor 15 (PAF15) undergoes UHRF1-dependent dual mono-ubiquitylation (PAF15Ub2) on chromatin in a DNA replication-coupled manner. This event will, in turn, recruit DNMT1. During early S-phase, UHRF1 prefe ...[more]