Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, LTQ Orbitrap Velos
ORGANISM(S): Rattus Norvegicus (rat) Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: Ling Li
LAB HEAD: Belinda Willard
PROVIDER: PXD015307 | Pride | 2020-03-09
REPOSITORIES: Pride
Gao Xing-Huang XH Li Ling L Parisien Marc M Wu Jing J Bederman Ilya I Gao Zhaofeng Z Krokowski Dawid D Chirieleison Steven M SM Abbott Derek D Wang Benlian B Arvan Peter P Cameron Mark M Chance Mark M Willard Belinda B Hatzoglou Maria M
Molecular & cellular proteomics : MCP 20200304 5
The redox-based modifications of cysteine residues in proteins regulate their function in many biological processes. The gas molecule H<sub>2</sub>S has been shown to persulfidate redox sensitive cysteine residues resulting in an H<sub>2</sub>S-modified proteome known as the sulfhydrome. Tandem Mass Tags (TMT) multiplexing strategies for large-scale proteomic analyses have become increasingly prevalent in detecting cysteine modifications. Here we developed a TMT-based proteomics approach for sel ...[more]