YBEY is an essential biogenesis factor for mitochondrial ribosomes
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Early Embryonic Cell
DISEASE(S): Mitochondrial Metabolism Disease
SUBMITTER: 
Goran Mitulović
LAB HEAD: Goran Mitulovic
PROVIDER: PXD015310 | Pride | 2020-03-02
REPOSITORIES: Pride
Publications
YBEY is an essential biogenesis factor for mitochondrial ribosomes.
Summer Sabrina S Smirnova Anna A Gabriele Alessandro A Toth Ursula U Fasemore Akinyemi Mandela AM Förstner Konrad U KU Kuhn Lauriane L Chicher Johana J Hammann Philippe P Mitulović Goran G Entelis Nina N Tarassov Ivan I Rossmanith Walter W Smirnov Alexandre A
Nucleic acids research 20200901 17
Ribosome biogenesis requires numerous trans-acting factors, some of which are deeply conserved. In Bacteria, the endoribonuclease YbeY is believed to be involved in 16S rRNA 3'-end processing and its loss was associated with ribosomal abnormalities. In Eukarya, YBEY appears to generally localize to mitochondria (or chloroplasts). Here we show that the deletion of human YBEY results in a severe respiratory deficiency and morphologically abnormal mitochondria as an apparent consequence of impaired ...[more]
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