Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Pan Fang
LAB HEAD: Huli Shen
PROVIDER: PXD015335 | Pride | 2019-11-25
REPOSITORIES: Pride
Fang Pan P Xie JuanJuan J Sang Shaoming S Zhang Lei L Liu Mingqi M Yang Lujie L Xu Yiteng Y Yan Guoquan G Yao Jun J Gao Xing X Qian Wenjing W Wang Zhongfeng Z Zhang Yang Y Yang Pengyuan P Shen Huali H
Analytical chemistry 20191219 1
Protein N-glycosylation is ubiquitous in the brain and is closely related to cognition and memory. Alzheimer's disease (AD) is a multifactorial disorder that lacks a clear pathogenesis and treatment. Aberrant N-glycosylation has been suggested to be involved in AD pathology. However, the systematic variations in protein N-glycosylation and their roles in AD have not been thoroughly investigated due to technical challenges. Here, we applied multilayered N-glycoproteomics to quantify the global pr ...[more]