Proteomics

Dataset Information

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STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells

ABSTRACT: STRAP protein was IP'd and corresponding binding proteins were identified by high resolution nanoLCMS2 vs a control experiment.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Primary Cell, Embryonic Stem Cell

DISEASE(S): Disease Free

SUBMITTER: james mobley  

LAB HEAD: james mobley

PROVIDER: PXD015371 | Pride | 2020-09-10

REPOSITORIES: Pride

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Dataset's files

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Mudpit_jm_201501118_LinJin_IgG1.mzid.gz Mzid
Mudpit_jm_201501118_LinJin_IgG1.mzid_Mudpit_jm_201501118_LinJin_IgG1.MGF Mzid
Mudpit_jm_201501118_LinJin_IgG1.mzid_Mudpit_jm_201501118_LinJin_IgG1.pride.mgf.gz Mzid
Mudpit_jm_201501118_LinJin_IgG1.pride.mztab.gz Mztab
Mudpit_jm_201501118_LinJin_STRAP1.mzid.gz Mzid
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Publications

STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.

Jin Lin L   Chen Yunjia Y   Crossman David K DK   Datta Arunima A   Vu Trung T   Mobley James A JA   Basu Malay Kumar MK   Scarduzio Mariangela M   Wang Hengbin H   Chang Chenbei C   Datta Pran K PK  

Nature communications 20201123 1

Alternative splicing (AS) is involved in cell fate decisions and embryonic development. However, regulation of these processes is poorly understood. Here, we have identified the serine threonine kinase receptor-associated protein (STRAP) as a putative spliceosome-associated factor. Upon Strap deletion, there are numerous AS events observed in mouse embryoid bodies (EBs) undergoing a neuroectoderm-like state. Global mapping of STRAP-RNA binding in mouse embryos by enhanced-CLIP sequencing (eCLIP-  ...[more]

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