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CFAP43 interactome mouse testis

ABSTRACT: CFAP43 along with its protein complex was purified from mouse testisby a CFAP43 specific antibody to identify the CFAP43-associated protein complex.

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis

SUBMITTER: Karsten Boldt

LAB HEAD: Dr. Karsten Boldt

PROVIDER: PXD015425 | Pride | 2020-01-09

REPOSITORIES: Pride

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CFAP43 modulates ciliary beating in mouse and Xenopus.

Rachev Ev E Schuster-Gossler Karin K Fuhl Franziska F Ott Tim T Tveriakhina Lena L Beckers Anja A Hegermann Jan J Boldt Karsten K Mai Michaela M Kremmer Elisabeth E Ueffing Marius M Blum Martin M Gossler Achim A

Developmental biology 20191227 2

Malfunctions of motile cilia cause a variety of developmental defects and diseases in humans and animal model organisms. Defects include impaired mucociliary clearance of the airways, sperm immotility, hydrocephalus and organ laterality. Here, we characterize the evolutionary conserved Cfap43 gene by loss-of-function experiments in the mouse and the frog Xenopus laevis. Cfap43 is expressed in tissues carrying motile cilia and acts as a target gene of the transcription factor FOXJ1, which is esse ...[more]

PMID: 31884020

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