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Acute Pulmonary and Serologic Changes in the Proteomes of Bromine Exposed Mice (lungdata)

ABSTRACT: Bromine is the most common organohalide found in nature. This halogen is often produced from sea brines and salt lakes. The primary producers and consuming countries of Br2 include the USA, Israel, Jordon, and China. The production of many products including brominated fire retardants (BFR’s), in addition to drilling fluids, agricultural materials, and biocides for the treatment of water all require Br2. While accidental exposure has occurred during production processes and transportation, a major concern is that larger storehouses of Br2 are potential targets for terrorist groups throughout the World. Higher concentrations of Br2 are life threatening within as little as 30 minutes. In our present study, we utilized the common C57BL/6 mouse model to survey the lung and serologic proteomes following exposure to near lethal levels of Br2 for 30 minutes. We describe detailed acute changes found within the global proteomes of these animals, in addition to post-translationally modified brominated proteins longitudinally over three time points from 30min to 96hrs post exposure. Through the application of common proteomics workflows combined with systems biology analysis, we were able to identify robust and highly significant biomarkers and pathways associated with Br2 exposure that are new to this model.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung

DISEASE(S): Wounds And Injuries

SUBMITTER: james mobley

LAB HEAD: James Mobley

PROVIDER: PXD015462 | Pride | 2020-06-18

REPOSITORIES: Pride

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