Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Streptomyces Coelicolor A3(2)
SUBMITTER: Ju-Hyung Lee
LAB HEAD: Jung-Hye Roe
PROVIDER: PXD015538 | Pride | 2020-05-27
REPOSITORIES: Pride
Lee Ju-Hyung JH Yoo Ji-Sun JS Kim Yeonbum Y Kim Jong-Seo JS Lee Eun-Jin EJ Roe Jung-Hye JH
mBio 20200414 2
Bacteria that encounter antibiotics can efficiently change their physiology to develop resistance. This intrinsic antibiotic resistance is mediated by multiple pathways, including a regulatory system(s) that activates specific genes. In some <i>Streptomyces</i> and <i>Mycobacterium</i> spp., the WblC/WhiB7 transcription factor is required for intrinsic resistance to translation-targeting antibiotics. Wide conservation of WblC/WhiB7 within <i>Actinobacteria</i> indicates a critical role of WblC/W ...[more]