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Human Glioblastoma Multiforme Tissue Proteome

ABSTRACT: Quantitative analysis of human glioblastoma multiforme (GBM) using Tandem Mass Tags (TMT) reagent. Mass spectra comprised with global proteome and phosphoproteome with standard channel.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Neoplastic

DISEASE(S): Brain Glioblastoma Multiforme

SUBMITTER: Shinyeong Ju

LAB HEAD: Cheolju Lee

PROVIDER: PXD015545 | Pride | 2020-07-06

REPOSITORIES: Pride

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Publications

Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities.

Oh Sejin S Yeom Jeonghun J Cho Hee Jin HJ Kim Ju-Hwa JH Yoon Seon-Jin SJ Kim Hakhyun H Sa Jason K JK Ju Shinyeong S Lee Hwanho H Oh Myung Joon MJ Lee Wonyeop W Kwon Yumi Y Li Honglan H Choi Seunghyuk S Han Jang Hee JH Chang Jong Hee JH Choi Eunsuk E Kim Jayeon J Her Nam-Gu NG Kim Se Hoon SH Kang Seok-Gu SG Paek Eunok E Nam Do-Hyun DH Lee Cheolju C Kim Hyun Seok HS

Nature communications 20200703 1

The prognostic and therapeutic relevance of molecular subtypes for the most aggressive isocitrate dehydrogenase 1/2 (IDH) wild-type glioblastoma (GBM) is currently limited due to high molecular heterogeneity of the tumors that impedes patient stratification. Here, we describe a distinct binary classification of IDH wild-type GBM tumors derived from a quantitative proteomic analysis of 39 IDH wild-type GBMs as well as IDH mutant and low-grade glioma controls. Specifically, GBM proteomic cluster 1 ...[more]

PMID: 32620753

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