Proteomics

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The crucial role of CPT2 in the asthmatic bronchial smooth muscle remodeling

ABSTRACT: Asthma is a very frequent airway disease that affects 6 to 20% of the population. Severe asthma, represents 3 to 5% of all asthmatic patients and is histologically characterized by an increased bronchial smooth muscle (BSM) mass and clinically by viral exacerbations. Functionally, BSM remodeling had a poor prognostic value in asthma, since higher BSM mass was associated with lower lung function and increased exacerbation rate. However, the role of BSM as a potential actor of asthma exacerbation has only been sparsely suggested. Thus, we hypothesis that asthmatic BSM cell metabolism is modified compare to that of non-asthmatic and that could be a potential target to reduce asthmatic BSM cell proliferation and remodeling in asthma.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Bronchial Smooth Muscle Cell

DISEASE(S): Asthma

SUBMITTER: Dupuy Jean-William  

LAB HEAD: Thomas Trian

PROVIDER: PXD015566 | Pride | 2021-06-10

REPOSITORIES: Pride

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<h4>Background</h4>Bronchial smooth muscle (BSM) remodelling in asthma is related to an increased mitochondrial biogenesis and enhanced BSM cell proliferation in asthma. Since mitochondria produce the highest levels of cellular energy and fatty acid β-oxidation is the most powerful way to produce ATP, we hypothesised that, in asthmatic BSM cells, energetic metabolism is shifted towards the β-oxidation of fatty acids.<h4>Objectives</h4>We aimed to characterise BSM cell metabolism in asthma both <  ...[more]

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