The crucial role of CPT2 in the asthmatic bronchial smooth muscle remodeling

ABSTRACT: Asthma is a very frequent airway disease that affects 6 to 20% of the population. Severe asthma, represents 3 to 5% of all asthmatic patients and is histologically characterized by an increased bronchial smooth muscle (BSM) mass and clinically by viral exacerbations. Functionally, BSM remodeling had a poor prognostic value in asthma, since higher BSM mass was associated with lower lung function and increased exacerbation rate. However, the role of BSM as a potential actor of asthma exacerbation has only been sparsely suggested. Thus, we hypothesis that asthmatic BSM cell metabolism is modified compare to that of non-asthmatic and that could be a potential target to reduce asthmatic BSM cell proliferation and remodeling in asthma.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Bronchial Smooth Muscle Cell

DISEASE(S): Asthma

SUBMITTER: Dupuy Jean-William  

LAB HEAD: Thomas Trian

PROVIDER: PXD015566 | Pride | 2021-06-10

REPOSITORIES: Pride