Dataset Information
TCHP partner proteins by LC-MS/MS
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Early Embryonic Cell
DISEASE(S): Myocardial Ischemia
SUBMITTER: 
Andrea Caporali
LAB HEAD: Andrea Caporali
PROVIDER: PXD015581 | Pride | 2020-04-29
REPOSITORIES: Pride
Dataset's files
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Publications
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy.
EMBO reports 20200426 7
Autophagy is an essential cellular quality control process that has emerged as a critical one for vascular homeostasis. Here, we show that trichoplein (TCHP) links autophagy with endothelial cell (EC) function. TCHP localizes to centriolar satellites, where it binds and stabilizes PCM1. Loss of TCHP leads to delocalization and proteasome-dependent degradation of PCM1, further resulting in degradation of PCM1's binding partner GABARAP. Autophagic flux under basal conditions is impaired in THCP-de ...[more]
