Dataset Information

LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription

ABSTRACT: Co-precipitated proteins from REG1CP RNA pull-down assay were separated by 12.5% SDS-PAGE and visualized by silver staining. The specific proteins associated with REG1CP were identified using liquid chromatography-tandem mass spectrometry (LC/MS). The MASCOT database search was applied to validate the data.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Colon Cancer

SUBMITTER: Hamed Yari

LAB HEAD: Xu Dong Zhang

PROVIDER: PXD015608 | Pride | 2020-01-13

REPOSITORIES: Pride

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LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription.

Yari Hamed H Jin Lei L Teng Liu L Wang Yufang Y Wu Yongyan Y Liu Guang Zhi GZ Gao Wei W Liang Jin J Xi Yanfeng Y Feng Yu Chen YC Zhang Chunming C Zhang Yuan Yuan YY Tabatabaee Hessam H La Ting T Yang Rui Hong RH Wang Fu Hua FH Yan Xu Guang XG Farrelly Margaret M Scott Rodney R Liu Tao T Thorne Rick F RF Guo Su Tang ST Zhang Xu Dong XD

Nature communications 20191125 1

Protein products of the regenerating islet-derived (REG) gene family are important regulators of many cellular processes. Here we functionally characterise a non-protein coding product of the family, the long noncoding RNA (lncRNA) REG1CP that is transcribed from a DNA fragment at the family locus previously thought to be a pseudogene. REG1CP forms an RNA-DNA triplex with a homopurine stretch at the distal promoter of the REG3A gene, through which the DNA helicase FANCJ is tethered to the core p ...[more]

PMID: 31767869

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	F001534.dat	Other
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	processedresults.xlsx	Xlsx